Sentence examples for base damage from inspiring English sources

γ-rays cause DSBs, single-stranded DNA nicks, and base damage (Ward 1990; Friedberg et al. 2006).

The BER pathway begins with recognition of base damage by a DNA glycosylase, which removes the damaged base [7], [8].

For example, ROS generated during increased metabolic activity in cancer cells generate DNA damaging lesions such as AP sites, oxidative base damage, DNA SSBs, and DNA DSBs.

Base damage typically halts DNA replication because most polymerases stall at damaged bases.

During the short-patch repair, after base damage, recognition occurs by a DNA glycosylase/lyase and subsequent cleavage of the damaged base occurs by AP endonuclease.

Therefore, the base damage award by the Court of Chancery amounted to $1.347 billion.

In addition, oxidative DNA base damage that induces potentially mutagenic lesions was observed in blood samples from doxorubicin-treated patients [18].

The proteins identified included early repair factors such as the base damage recognition glycosylases OGG1 and MYH and the late repair factor POLß, implicating the entire BER pathway.

Paraquat mainly causes single-base damage which is corrected through base excision repair pathway.

It was previously shown that WRN participates in the repair of MMS induced DNA base damage via both short patch and LP BER [22], [26], [36].

Each glycosylase recognizes specific base damage; for example, Ogg1 recognizes oxidatively damaged guanine as 8-oxo-guanine (8-oxo-G) or formamidopyrimidine-guanine (Fapy-G) [8].