Contrary to many approaches, we refrained from choosing a base compound (such as collagen), that in itself may exert cell regulative properties towards chondrocyte-like cell types as they are found in intervertebral discs.
More recently platinum based compounds such as cysplatin and carboplatin have become the chemotherapeutic agents of choice for many cancers [ 19].
Oil-in-water formulated, squalene based compounds such as MF59, AF02 and AS03 are promising new proprietary adjuvants for intramuscular influenza vaccines.
Recent investigations have demonstrated that inhibition of breast cancer cell proliferation by certain plant based compounds such as Curcumin and the flavanoidal compounds quercetin and taxifolin [ 23], may in part be mediated via significant inhibition of HSP expression in these cells.
Peltophorum pterocarpum leaves have been reported to have many anti-oxidant based bioactive compounds such as quercetin 3-O-galactoside, methyl derivatives of quercetin, naringenin, luteolin and various other anti-oxidant based compounds [9, 15].
These data suggest that there may be a need for improved therapeutic strategies based on compounds such as iota-carrageenan.
Indeed, broad based polyanionic compounds, such as heparin and PEI, have been reported to inhibit PrPSc infection of cells [50] [52], potentially by sequestration of the N-terminal PTD.
- Several plant based polyphenolic compounds such as green tea, grape seed and pomegranate showed some protection in vitro, and it has been suggested that they may reduce photoaging and photocarcinogenesis.
So far, it is not yet clear what an adequate intake is: neither is it clear whether it should be based on individual compounds, such as -epicatechin, or a group of compounds such as cocoa flavanols, nor is it clear which amount should be recommended.
