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More than 90%% of base changes induced by EMS and NMU are known to be G to A and C to T transitions [ 18].
It is possible that some small RNA-derived reads have natural mutations, RNA-editing or base changes induced by the experimental protocol.
A caveat is that the single base changes induced by ENU are well-known to cause both hypomorphic and neomorphic alleles.
Among all single base changes induced by EMS, 69.5 % (9,667) were transitions and 30.5%% (4,245) were transversions (Fig. 5).
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The aim of the study was to investigate the response of the kidney to plasmatic acid-base changes induced by dilution with three crystalloid solutions at different SID.
We chose to determine the expression of these markers in hypothalamus and cortex based on the behavioral changes induced by EE in our RTT mouse model and WT mice.
DSC- and ssCE-MRI are based on detection of signal changes induced by intravascularly injected exogenous contrast agents, while ASL exploits endogeneous contrast mechanisms involving magnetically labeled arterial water.
Comparing the expression patterns using all the 54,675 probes representing all the genes in the human genome or using 45 probes selected based on fold of expression changes induced by E2, action of SWT is similar to E2 in particular when focusing on the 45-probe "estrogen-responsive genes".
The second main finding of the present study is our potential ability to predict, with limited bias and correct precision, individual tumour size changes induced by chemotherapy based on CA-125 kinetics.
Using the validated model, we could predict with accuracy the tumour size changes induced by chemotherapy based on the baseline imaging assessment and longitudinal CA-125 values (mean prediction error: 0.3%, mean absolute prediction error: 10.6%).
Statistical analysis of the changes induced by ZD6126 treatment were based on the change in the proportion of highly enhancing pixels.
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