Sentence examples for base change at the from inspiring English sources

Validation of SNPs in the cp rbcL and matK regions of 36 accessions belonging to C. quinoa and C. album was performed by allele-specific PCR with primers carrying a single base change at the 3′ end.

A base change at the interrogated CpG would cause an otherwise methylated site to be considered unmethylated.

To confirm that inhibition of Drosha cleavage is due to ADAR2 binding rather than because of the base change at the edited site an active site-mutant ADAR2 E319A was co-expressed.

Interestingly, an A>G base change at the human equivalent of G524, namely 249A (m.896appearsars in 20 GenBank sequences and in a MITOMAP unpublished sequence (http://mitomap.org/bin/view.pl/MITOMAP/Submissions/20100804015).

Each probe pair consists of a perfect match sequence that is complementary to the cRNA target and a sequence that is mismatched by a single base change at the middle of the nucleotide, a region critical for target hybridization.

A second polymorphism has been identified in the second 28 bp repeat of 3R alleles, consisting of a G>C base change at the twelfth nucleotide, which makes the transcriptional activity of the 3R allele as low as that of the 2R allele (Mandola et al, 2003).

Base changes at the same site were counted as one base change.

Base changes at the most strongly conserved positions 2 (alanine for thymine) or 5 (guanine for cytosine) of v1 caused this affinity to drop ∼1,000-fold ∼1,000-fold

To the tube with codon 12 primers, we added two more primers to detect the base changes at the first and second bases of codon 13 (41mer sense strand for the first base; 49mer antisense strand for the second base).

In agreement with the important role of this region in translation, mutagenesis studies performed in yeast have shown that several base changes at the equivalent positions to 926, 927 or 928 confer lethal phenotypes (56).

In adults, active tobacco smoke exposure has been found to increase the frequency and proportion of small base changes at the HPRT gene [ 33], consistent with the known mechanisms of tobacco smoke mutagens and the types of mutations found in oncogenes in smoking-associated cancers [ 34, 35].