It is shown that the most economically attractive configuration is Petlyuk with bottom flashing with total annual costs (TAC) saving of 43.4% (compared to 9.58 mUSD/year TAC of the base case), while the best performances of vapor recompression systems were obtained on Petlyuk and side stripper designs with TAC savings of 37.4 and 31.0%, respectively.
For efficacy assessments, labelled doses for OA treatment were used for the base case while labelled doses for RA treatment were also included in the sensitivity analysis.
Proving \(P 0)\) is of course the base case, while proving \(∀n, (P(n)\implies P(n+1))\) gives the inductive step.
About 70% of the metabolites have zero flux-sum in the base case while metabolites with high and ultra-high ((1) ) basal flux-sums were mostly essential cofactors that are involved in oxidative phosphorylation and redox reactions with a high degree of participation in basal active reactions (i.e. reactions with nonzero basal flux).
The thick grey lines below represent the base case scenario, while the green and purple lines represent the upside and downside scenarios, respectively.
The thick grey lines below represent the base case scenario, while the blue and green lines represent the upside and downside scenarios respectively.
If only one out of the three hospitals implements screening, the total investment costs are $0.8 m 7.8.8%) higher than the total investment costs of the 3 hospitals in base case scenario, while the number of infections averted in the participating hospital diminishes by 254 (−11.5%) (158 infections are averted in each of the non-participating hospitals).
25, 29– 31 Costs from Yu et al 31 were used for the base case results, while the cost of exacerbations was varied using data from Earnshaw et al 25 and Oba 29 in our scenario analysis.
In the first case scenario the overall survival rate was fixed for the Dox regimen at 76% as in the base-case model while the rates for the alternative regimen were decreased by 10% for each subsequent analysis.
In the base case scenario, the costs remained almost constant while in the vaccine scenario they decreased from 102,074 to 86,926 Euros per 1,000 children (Fig. 3).
