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Base case values were modified for the following parameters: Transition probabilities: The same values applied for methadone were also assumed for B/N combination.
For this work, the base case values were taken from the NREL Design Report default cases [ 39].
95% confidence intervals around the base case values were derived using standard deviations calculated from the 5000 simulations in the PSA.
The base case values were increased with 25%% for all parameters except for the number of short term sick leave days that was increased with 50%%.
The superior cost-effectiveness of IGRA was not threatened when base case values were inflated 10-fold for all-cause death rates, TB death rates, prevalence of LTBI or TB, relapse rates and hepatitis rates (figure 2E, supplementary table 3a f).
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The percentage changes of the decision variables compared to their base case values are found to be similar for all the voltages other than the voltages close to the open circuit potential (OCP).
Small reductions in vaccine coverage, in the duration or degree of protection, from their base case values are sufficient to prevent elimination of VT being achieved.
One-way sensitivity analyses varying one parameter, while holding other parameters at their base case value, were performed.
The base case value is assumed to be 0.3 mg/g rock based on the average laboratory measurement.
The base case value is represented by the central vertical line and the outcome values are plotted for the maximum and minimum values of each selected parameter.
Table 6 demonstrates the sensitivity analysis results; for each parameter that was varied the value in the base case is shown, in addition to the resulting ICERs when the base case value was either increased or decreased by 20%.
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