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8 See table 1 for base case values and sources for data inputs.
Table 6 shows the parameters included, the base case values and the parameters ranges used in the sensitivity analyses.
The deterministic model developed was used to estimate base case values, and a stochastic version (with Monte Carlo simulation) was used to perform multivariate sensitivity analysis.
A deterministic decision tree model was used to estimate base case values, and a stochastic version, with Monte Carlo simulation, was used to perform sensitivity analysis.
The literature reviewed aided in the selection of the base case values and ranges for the incremental resource utilisations and outcomes.
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Tables 2 and 3 show variables used with its base case value and distribution.
In the sensitivity analyses, the lower and upper bounds of the transition rates and QALYs were obtained from published studies; the costs were varied by increasing and decreasing the base case values by 25%; and the lower and upper bounds of the SVR rates were obtained from the bounds of their respective 95% confidence intervals on the reported values.
We computed distributions for the parameters using base case values as means, and standard errors calculated from uncertainty ranges (Table 1).
Simulation results indicated that all of the vaccination strategies considered in this paper were sufficient to eliminate VT transmission in England and Wales with base case values for vaccination coverage and other parameters.
When the efficacy of PR48 was assumed to be 45.4%, the upper limit of the 95% confidence bound, and the efficacies for BOC/RGT and BOC/PR48 remained the base case values, the ICERs of BOC/RGT and BOC/PR48 increased to $29,369 and $81,237, respectively.
Sensitivity analyses will be conducted by testing a 20% range versus base case values for cost parameters and effectiveness measures, as well as using probabilistic sensitivity analysis approaches [ 26].
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CEO of Professional Science Editing for Scientists @ prosciediting.com