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For the antenatal and intrapartum transmission rates, the base case uses the midpoint of the range of estimates (25%), and the sensitivity analysis uses the lower (19%) and upper (30%) bounds.
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Our base case used the stepwise dose response from WHO (2004) (Table 1).
Our base case used the FVC % predicted where reported, as by definition this includes adjustment for age and sex.
In the base case, using the trapezoidal method of AUC calculation, the relative order of performance remained fairly consistent across the three outcome weights.
The base case uses an intervention threshold for maternal blood of 3.4 μg/L.
This is the base case used in the model.
Summary of utilities and disutilities for the base case used in the model.
Using values elicited by Brown et al using the standard gamble technique generated an ICER of £5126.51 (21% higher than the base case using time trade-off values from the same source).
The model base case used a hypothetical cohort comprising of 1000 surgeries in the first year and followed a 5.2%% annual increase each year.
The base case used a much more conservative estimate of 49% tolerance[ 3].
We defined the method of identifying incident fall-related hip fracture from linked data as the reference standard and calculated the sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) for the base case using standard definitions [ 26].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com