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The base case scenario showed that escitalopram had an incremental cost-effectiveness ratio (ICER) of €4395 and €1080 per QALY compared with sertraline and paroxetine, respectively.
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The base case scenario shows a positive return on the investment between five and eight years after the intervention.
The base-case scenario showed that tiotropium was associated with an approximately 16% reduction in exacerbations when compared with salmeterol.
Line One of the table shows results from the base case scenario; we show the cost-effectiveness of evaluation and treating active cases only, the incremental cost-effectiveness of treating TB4s, and finally the overall cost-effectiveness of evaluation and therapy for active cases, individuals in class TB4, and individuals in class TB2.
Summary results from our base case scenario are shown in the first line of Table 6.
The main parameters used in the base case scenario are shown in Table 5. Cost data (€, 2011) were collected from the National Tariffs [ 15] and, when not available, through the international literature adjusting for currency and inflation [ 16– 16].
Sensitivity analysis showed that the results were most sensitive to variation in the time horizon and assumptions on the duration of the benefits of pioglitazone treatment observed in the trial, whilst the exclusion of improved β-cell function from the base case scenario was shown to bias against pioglitazone (see Additional file 3).
The best-case scenario showed it ending in the middle of next year.
Table 5 shows the parameters used in the base case scenario and Table 6 those used in LCD option scenario.
Table 1 shows the key outputs under the base case scenario for the screened and unscreened cohorts.
Table 8 shows the results of the analyses of the base case scenario with different discount rates.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com