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Sensitivity analyses confirmed the base case result to be robust.
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The base case result was not sensitive to the discount rate (see Table 6).
The base case result was not sensitive to alternative data and methodology but considerably affected by sustainability assumptions.
Sensitivity analyses showed that the base case result was not sensitive to any single parameter other than unit costs.
This also makes our base case results comparable to the study by Hayes et al. who assume that AS would be 25% more effective than WW, implying a RR of 0.82.
This approach lends itself to the clinical setting where the risks are continuous over time, key events may be repeated and operational factors may interact with other key parameters to influence the base case result.
36 A univariate sensitivity analysis was then performed on cost values in order to assess variations in the base case and to identify threshold values for which the base case result showed significant variations.
In the base case result with a 85% vaccination rate the cost per QALY gained by female vaccination (compared to no vaccination) was € 3,581 when including all HPV-related diseases in the analysis (Table 4).
The top line shows the base case result and represents the scenario of aspirin resulting in a 50% reduction in 5 year cumulative EAC incidence.
We found that accounting for future costs did not significantly alter the base case result.
The base case result of ICER 1,124 Int$/LYG is highly cost-effective in our local context.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com