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The base case ratio of life-saving absolute benefit high/low subsets is 130 (4.3/0.034).
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We compared alternative cost effectiveness ratios on the basis of these imputed full sample costs and outcomes with the base case ratios.
Compared to other medical interventions, the base case cost-effectiveness ratio of $321,000/QALY was relatively expensive.
The first column of this table shows the base case hospitalization risk ratio reported in the CATIE, phase 1 [ 23].
For the base case analysis, this ratio was expressed in 2007 Indian rupees per life year saved and was calculated as the difference in mean cost under the vaccination strategy compared with that under the no vaccination strategy divided by the difference in years of life lost between the two strategies.
In the base case analysis hazard ratios for all-cause mortality were available for three studies and binary data were available for the remaining 37 studies.
The results of the probabilistic analysis, which varied the event rates, costs, and utilities, support the deterministic base case results with a ratio of $9,9429595% CI $9,764 $10,120) per QALY, with 93% probability of a ratio below $20,000 per QALY gained.
The base case incremental cost-effectiveness ratio for botulinum toxin A plus therapy was 93,500£ per QALY gained.
The incremental cost effectiveness ratio (base case) was £43 485 per QALY.
Three sensitivity analyses tested the robustness of the base case incremental cost-effectiveness ratio (ICER).
At a discounted rate of 3% the incremental cost effectiveness ratio (base case) was £43 485 per QALY (table 2).
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