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In our base case model, we assumed that generic versions of dabigatran etexilate would be introduced 7 years after model initiation and at 25% of the patented drug cost, but this may not be the case.
In the base case model, we assume each bed net - whether conventional or long-lasting - has a 3-year lifespan and costs USD 4. For an LLIN to be approved by the WHO Pesticides Evaluation Scheme (WHOPES), at least 80% of the nets must pass tests for effectiveness after being used by households in randomised field trials lasting at least 3 years [ 41].
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Thus, in our base-case model, we halved the VE for this age group.
In the base-case model, we estimated the efficacy of antiviral treatment for preventing hospitalization as 59% (20 ).
In the base-case model, we assumed that women with normal glucose in pregnancy did not develop diabetes later in life.
In our base-case model, we estimated that in a pandemic, ILI would develop in 28.1% of the population (16.8 million persons) (including 15 million pandemic influenza patients).
In the base-case model, we assumed a stockpile purchase price for pharmaceuticals of $12 per vaccine dose and $32 per antiviral course; a range of values was considered in sensitivity analysis.
The base case model duration was 5 years; however, we also explored models from 2 to 15 years.
As discussed earlier, we have populated the base case model relying on simplifying assumptions to avoid erroneous conclusions about the screening test itself.
We conduct a deterministic sensitivity analysis of the base case model to assess the impact of each effect parameter, including the probability of having no complications, on costs.
In the E-milling model presented here, we used fairly conservative values for starch yield improvements over the conventional base case model.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com