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Model adequacy was evaluated by comparing the predictions to a base case model in which the dependence of the reaction rate on the nonuniformity of the surface was rigorously taken into account.
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These three groups of variables were first added to the base case model independently in order to assess their separate association with years traded off.
13, 14 The base-case model in the current study assumes that patients were treated with dronedarone for 21 months (the mean duration of follow-up in the ATHENA trial).
Firstly, the base case model assumes that in the absence of a prosthesis failure, any differences in quality of life between prosthesis types are maintained over the patient's lifetime.
In addition to process design changes for the deacetylation, mechanical refining, and hydrolysate solids washing options, several important cost assumptions that are different from the 2011 NREL design base case model are incorporated in the model and listed below: All yields are based on results from bench-scale experiments from the companion paper [ 8].
The ICER in the base case rose to $40,841 per QALY in a base case model with a 30% reduction in POB risks.
The base case model was generally robust, in that the pattern of results remained similar with alternative assumptions, even if metal-on-metal prostheses were excluded (table 5).
The values used in the base case model, one-way sensitivity analyses and replenishment scenarios are summarised in Table 1.
It is not clear exactly how to model the effect of just barely meeting the HEDIS requirement of one filled prescription in a year, but our "base case" model presumes that most patients with asthma in a HEDIS denominator population who receive a prescription are taking medications as regularly as patients in the studies reviewed.
This assumption is used in our base case model.
Other variables take values specified in the base case model (Table 1).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com