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The base case model assumed all patients were on dialysis.
The French authorities have approved generic forms of alendronate 70 mg in 2006 [ 32], and although risedronate is still protected by a market patent, the base case model assumed by default the generic price of alendronate for bisphosphonates corresponding to €52.23 for 12 weeks of treatment.
Our base case model assumed that transmission is proportional to the number of infectious cases and number of susceptible cases (mass action); if this is not the case, then this may have masked increased transmission at the later, lower prevalence (Lietman et al., 2011).
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Firstly, the base case model assumes that in the absence of a prosthesis failure, any differences in quality of life between prosthesis types are maintained over the patient's lifetime.
The base-case model assumed no patients on add-back therapy and this, in itself, is a simplifying assumption.
The base-case model assumed that patients were treated with dronedarone for the duration of ATHENA (mean 21 months) and were followed over a lifetime.
The base-case model assumed that patients received each treatment that they initiated for as long as they continued to respond, with the exception of rituximab, which was assumed to be given for a single course only.
The base-case model assumes that patients with no or mild fibrosis who are treated incorrectly (test diagnosis of FP) benefit from antiviral treatment.
In our base case model, we assumed that generic versions of dabigatran etexilate would be introduced 7 years after model initiation and at 25% of the patented drug cost, but this may not be the case.
In the base case model, we assume each bed net - whether conventional or long-lasting - has a 3-year lifespan and costs USD 4. For an LLIN to be approved by the WHO Pesticides Evaluation Scheme (WHOPES), at least 80% of the nets must pass tests for effectiveness after being used by households in randomised field trials lasting at least 3 years [ 41].
The base case model population was assumed to be similar to that of the UPLIFT trial in terms of age (65 years), disease state (GOLD II IV), risks of exacerbations and the usual care received (non-LAMA).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com