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Indirect costs such as sick leave or early retirement were not incorporated into the base case model as these costs are not relevant from the perspective of the statutory health insurance.
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This base case model served as a comparator against which the effect of alternative parameter values and assumptions was explicitly explored.
The base case model was set as a square cross-sectional area with a dimension of 0.7 mm×0.7 mm and a length of 20 mm.
The same current intervention CostDNV (hospitalization) and ENV (disease-specific mortality) variables are used as in the base case model.
As such, the base case model adjusts for the cost of blindness on the basis of treated eyes reaching the BCVA ≤35-letter threshold.
As discussed earlier, we have populated the base case model relying on simplifying assumptions to avoid erroneous conclusions about the screening test itself.
The base case model assumed all patients were on dialysis.
It was added separately to the base case model.
Table 1 shows the results of the base case model.
This assumption is used in our base case model.
The probability of liraglutide 1.2 mg being a cost-effective therapeutic option at a willingness-to-pay threshold of €30000 per QALY gained was above 70% (72.5%).> -wrap-foot>> -wrap-foot> *Values shown are mean (SD) cumulative incidences over patient lifetimes from the base case modelling simulation expressed as a percentage of patients experiencing events.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com