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As a result of these limitations, we would recommend using the more conservative approach (the linear function derived from Equation 3 of Bauch et al. (2009) [ 12]) as the base case for cost-effectiveness analyses using a static model.
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The first is a conservative approximation, recommended as base-case for cost-effectiveness evaluations.
The first is a conservative approximation, recommended as a base-case for cost-effectiveness evaluations.
In relation to the optimal rescreening strategy, the base case probabilities for cost effectiveness were relatively close across the alternatives and for that reason, even marginal impacts of alternative assumptions could have affected the results.
In the base case analyses, the cost-effectiveness ratios for pneumococcal vaccination in preventing cases of BPD alone vary between €11,0000 and €33,0000 per QALY among the five countries.
If hospitalization rates were simultaneously half their base case values, the cost-effectiveness ratio was $896,000 per QALY.
Table 3 presents the base case results for the cost-effectiveness analysis and shows the total costs and QALYs associated with prophylaxis with palivizumab and no prophylaxis based on hypothetical cohorts of 100 infants within each of the subgroups.
The base case incremental cost-effectiveness ratio for botulinum toxin A plus therapy was 93,500£ per QALY gained.
Three sensitivity analyses tested the robustness of the base case incremental cost-effectiveness ratio (ICER).
The results for the base case of the deterministic cost-effectiveness analysis are summarized in Table 3.
In the base case analysis, the incremental cost-effectiveness ratio for bCPAP relative to nasal oxygen therapy was determined to be $4.20 (95% confidence interval, US$2.29 US$16.67) per LY gained.
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