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Base case estimates of frequency and costs of ADEs were lower than all estimates of the sensitivity analyses.
The base case estimates of the cost per QALY averted for the complete intervention and the condom use skills component fell below this $50,000 threshold.
Figure 4 displays base case estimates of the total mean direct medical cost, as well as predicted costs for each of the key cost components for all comparators in the model.
The estimates of yearly costs (including VAT) are shown in Table 4 and Table 5. Base case estimates of the non-pharmacological treatment-related costs of prevention, diagnosis, and treatment of hypertension in the ACCG and PCP scenarios are presented in Table 6.
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In our base case estimate of BIR costs in physician practices, we included 50% of the cost of coding.
The base case estimate of the number of HIV infections averted is 189 with a range from 144 to 227.
Summing the costs across the four analyzed segments of the population produces a base case estimate of approximately $3 billion from Trasande's linear model.
As shown in Table 5, the base case estimate of the number of HIV infections averted is 158 with a range from 120 to 189.
The base case estimate of this cost (£414) was calculated on the assumption that women wrongly identified as depressed would receive all of the supportive care associated with structured psychological therapy before being identified as not depressed.
Conversely, replacing the base case estimate of the main clinical results with the 95% CI limits as well as reductions in the DRG 410 DH tariff have a negligible effect on ICER amount.
Combined incremental variation of treatment time (to 10 minutes), capacity utilization (to 125%) and linear accelerator staff numbers (to 3) resulted in a decrease in the base case estimate of total costs for long-course radiotherapy (25 fractions) of 35%, from €3,609 to €2,354.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com