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The base case estimated a QALY gain of 0.037 and an ICER of US$214,085/QALY over 1 year.
Over the 5-year period, the base case estimated that OLAI produced an additional 0.07 (SD 0.019) discounted QALYs gained and 0.04 (SD 0.025) LYs gained per patient with a dominant discounted incremental cost savings of €2,940 (SD 300.83) and a dominant ICER per QALY and per relapse avoided compared with RLAI.
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Base case estimates showed that condom distribution averted 1/4 of HIV transmissions.
Base case estimates of frequency and costs of ADEs were lower than all estimates of the sensitivity analyses.
Table A of the appendix (online) presents the corresponding percentage change over the base case estimates for other scenarios.
The base case estimates that 2.14 million adults would develop ADEs during the course of ambulatory medical treatment in 2007.
Varying deterministic base case estimates by 20% (constrained by maximum and minimum values) shows that the model is most sensitive to the QoL estimate of a "well" person.
Our a priori decision to base our analysis on the entire RE-LY study population may limit the generalisability of the base case estimates to a UK context.
The base case estimates for probability of achieving an improved HDDS or FCS outcome were taken from the LIG survey [ 20].
Base case estimates for both 6 and 8 years demonstrated that cost-effectiveness improved as the time horizon lengthens with £13,626 (€21,840) and £11,000 (€17,631) cost per relapse avoided respectively.
The base case estimates demonstrated that the OLAI strategy resulted in an additional 0.07 (SD 0.019) QALYs and 0.04 (SD 0.025) LYs gained per patient.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com