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In our base case estimate, we assumed 0% effectiveness for a single dose of vaccine and 63% effectiveness for a second dose administered 4 weeks later for children <9 years, and we estimated that vaccination prevented 52,081 100,349 clinical cases among persons in this age group (Table 9).
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In our base case estimate of BIR costs in physician practices, we included 50% of the cost of coding.
The median cost is our base case estimate.
The base case estimate for the utility associated with this state assumes life-long sequelae [ 13].
This is 70% higher than the base case estimate which modelled the observed screening behaviour in the population.
The ranges for costs were varied from minus 25% to plus 25% of the base case estimate.
The base case estimate of the number of HIV infections averted is 189 with a range from 144 to 227.
*The epidemic curve that was used to generate these estimates was the base case estimate, which was based on the assumption that a vaccination program did not exist.
This estimate was less favourable than the base case estimate because the short time horizon did not take into account long-term benefits associated with ivabradine.
Changing capacity utilization from 100%to80%0% caused the base case estimate to increase by 16%-19%; increasing utilization to 125% reduced the total cost by 13-15% across courses.
Summing the costs across the four analyzed segments of the population produces a base case estimate of approximately $3 billion from Trasande's linear model.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com