We performed five one-way sensitivity analyses to check the potential influence of base case assumptions on our study findings.
On our base case assumption of £25m synergies in 2013, the deal is mid single-digit earnings accretive next year.
"We have used a base case assumption of a £200m issuance, as, on our forecasts, this is required to take the net debt/earnings ratio below 3x for 2009.
As a result, our trial-informed base case assumption of 67.1%% pain relief will need to be confirmed by future studies with a larger sample size.
Our base case assumption of a 20% RRR due to screening may be optimistic and is probably closer to 15% [ 29, 31].
Therefore, under the base case assumption of a high-volume screening initiative, one screening team could implement close to population-wide coverage in the target age group if screening were conducted over a 4 5 year period.
Under the base case assumption of a high-volume screening initiative (11,475 women screened annually per county), the aggregated direct medical costs of visual inspection, self-sampled careHPV (Qiagen USA) screening, clinician-sampled careHPV, colposcopy and biopsy were estimated as US$2.64 ,$7.49 ,$7.95 ,$3.90d $5.76, respectively.
Figure 3, Part A, shows the impact of varying our base case assumptions (probability of late failure, 0.021) from no late failure to a 2-fold increase in late failure.
Table 2 shows the cost and QALYs gained by the introduction of vaccination, over the 100 years after the introduction of the vaccine, assuming base case assumptions (vaccination of girls at age 12, 80% coverage, quadrivalent vaccine, and no catch-up programme) and vaccine protection lasting on average 20 years.
Under base case assumptions, adoption of the structured clinical interview as a confirmatory test proved to be cost saving compared with the equivalent strategy without the interview, although no strategy subsequently proved to be cost effective based on a threshold of £20-30 000 per QALY.
