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In our model, the base case assumption was that IOPTH improves the operative success rate from 96.3 to 98.8%.
The base case assumption was that in well-localized PHPT, IOPTH monitoring would increase the success rate of MIP from 96.3 to 98.8%.
The base case assumption was vaccination of girls aged 12 years using a school based programme, with 80% vaccine coverage (just under 400 000 girls) for the full three doses, on the basis of reported coverage in a trial of a school based hepatitis B vaccination programme.
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On the basis of these experiences, our base case assumption is that coverage will be 80% at age 12 13 and somewhat lower at older ages (Table 2), but we also present estimates based on 70 and 100% coverage at age 12 13.
Base case assumptions are outlined below.
The overall benefit given the base case assumptions is €9.4 billion.
For example, if 6% of deaths are preventable (as estimated by Hayward and Hofer), and base case assumptions are made (cM=0.2, cV=0.4, R=0.8), it follows that Q cannot exceed: (or about 0.079 if the alternative assumption A2′ is preferred).
Predicted ICER under the base-case assumption was 24,473,836 ($21,658) per QALY.
Given the uncertainty in the proportion of all H1N1 influenza patients who also had a bacterial coinfection, the base-case assumption was halved, resulting in a multiplier of 2.5 on pneumococcal disease incidence during a pandemic influenza season.
S&P said that it realised that next May's general election could lead to a change in fiscal plan, but still believes the Britain could achieve a budget surplus within five years: Our base-case assumption is that the next government will not abandon the goal of arriving at a position where the U.K. could start to pay down the stock of debt in absolute terms during the fiscal year ending April 2019.
(3) Assuming $17,645 benefit per infection averted, all evaluated strategies using base-case assumptions are cost-saving with the exception of universal screening with PCR in a medium prevalence setting.
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