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While in this analysis the point estimate for cost effectiveness suggested "dominance" of larval therapy that is, larval therapy being better and cheaper than hydrogel the uncertainty associated with this result was consistent with the base case analysis suggesting no difference between larval therapy and hydrogel in terms of health benefits or costs.
Results of the base-case analysis suggest that TF-CBT + SSRI is more cost-effective than TF-CBT alone, however, considering the uncertainty associated with prescribing SSRIs to children and adolescents, clinicians and parents may exercise some caution in choosing this treatment alternative.
The base-case analysis suggested a reduction in the overall number of pertussis cases in infants by 26% [ 87].
A 3.5% discount rate for both costs and benefits was used in the base case analysis as suggested by the current National Institute of Health and Clinical Excellence NICEE) guidelines.
The cost effectiveness acceptability curve (fig 2), plotted for a range of willingness to pay thresholds (cost per QALY), suggests that in the base case analysis the probability of larvae being cost effective in relation to hydrogel never exceeds 63%.
Although we did not include this scenario as our base case analysis to provide a more conservative estimated benefit, recent Canadian data suggest that these protective effects may be even larger than those anticipated in our analyses.
The timeframe of the base case analysis was 5 years.
The base case analysis includes all costs.
a The base case analysis and complete case analysis are based on the societal perspective.
This cost estimate is used in the base case analysis.
CPU care therefore dominates in the base case analysis.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com