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In the base case analysis, it was assumed that all infants hospitalised with RSV disease would experience additional respiratory sequelae (respiratory morbidity) related resource use for two years compared to non-admitted infants.
In the base case analysis, it was assumed that children who developed asthma or allergic sensitization were affected by these conditions until the age of 18 and not afterwards.
In the base case analysis it was assumed that when data on follow-up telephone sessions were missing, no sessions had taken place and the missing data were imputed with zero.
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In the base-case analysis, it was assumed that only hip fractures would potentially incur long-term care costs (associated with residence in nursing homes).
In the base-case analysis, it was assumed that a 100 mg vial would be used for the majority (95%) of administrations of palivizumab.
In the base-case analysis it was assumed that the benefits of anastrozole would continue out to 10 years from initiation of treatment.
Therefore, in the base-case analysis, it was assumed that 50% of children diagnosed with MCAD receive a supplementation in L-carnitine until the age of 18 years, after which the supplementation is stopped.
In the case of informal care, rather than the cost of a homecare worker used in the base-case analysis, it was assumed a cost per hour equivalent to the national minimum wage (£5.35).
The TEMPO trial was included in the base case analysis as it was the pivotal trial for etanercept in this patient population.
The timeframe of the base case analysis was 5 years.
In addition to the base case analysis, 3 alternative scenarios were explored.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com