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Example of absolute patient numbers from base case analysis in brackets.
The efficacy of splenectomy, romiplostim, and rituximab varied by 50% below the base case analysis in sensitivity analyses.
Concerning the costs, the costs of splenectomy, rituximab, and emergency treatment varied by 50% above and below the base case analysis in sensitivity analyses.
In the base case analysis, in the current scenario, the total economic impact of treatment with oral opioids for patients with BTcP was estimated at €119 million, €122 million, €127 million, and €133 million for the years 2012, 2013, 2014, and 2015, respectively (Table 5).
The base case analysis in a cohort of 1763 patients undergoing cataract surgery showed that when Mydriasert substituted mydriatic eye drops, annual total costs decreased by 18%% and annual total nurse time decreased from 235.1 hours to 44.1 hours over one year (2012 2013).
In prior studies, labour costs have tended to comprise a major part of VIA costs; for example, personnel costs comprised more than half of the aggregate costs in India, Thailand, Kenya and Ghana [ 7, 9, 11, 12], whereas in our base case analysis in China we found that this proportion was approximately one third of the total cost.
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Our results demonstrate that, on average, GXR is more efficacious than ATX for the treatment of ADHD in children and adolescents; these results demonstrated consistent significant reductions in symptoms in GXR over ATX in the base case analysis and in several of the sensitivity analyses.
In the base case analysis, patients in the intensive treatment arm were assumed to attend the specialist clinic at the Steno Diabetes Center.
The study by Simon and colleagues [ 36] used these estimates in the base case analysis, and in the sensitivity analysis the study investigated the effect of partial response to treatment using uncertainty ranges of 0.30 to 0.63 and 0.63 to 0.70 for severe and moderate depression, respectively.
The base case analysis resulted in an ICER of US$45,033/QALY.
Bird et al. concluded that there was much uncertainty surrounding the base case analysis, particularly in CT-positive patients.
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