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Intervention cost for base case analysis considered no extra time for pre-operative fluid loading, 30 minutes doctor's time and 42 minutes nurse's time.
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Our base-case analysis considered a hypothetical cohort of 12-year-old girls.
The base-case analysis considered only the period during which patients were active trial participants.
However, their threshold values were outside plausible ranges found in the literature, and very far from values considered in our base case analysis, which were conservative when considering the "Medical Interview" strategy.
In the base case analysis, the all-cause hospital admissions were considered.
In the base case analysis, CV and non-CV mortality was considered separately.
Administration costs were not considered for the base case analysis because they were regarded as negligible, given that erlotinib is administered orally.
Drug costs, primary care (PC) clinician visits, specialist visits, procedures, hospitalizations, and LSR management were considered in the base case analysis.
A total payer perspective (assuming a per diem basis of payment) was considered in the base case analysis, which was comprehensive and comprised all inpatient and outpatient health-care costs (antibiotic and medical).
Given the funding source, we estimated costs from the societal perspective in the base case analysis and given the decision-making context, considered the health systems and community care perspectives in scenario analyses [ 16].
Doctor and hospital unit costs were considered as detailed for base case analysis.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com