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The base-case analysis conducted using the decision analytical model included all grades of adverse events, using as a threshold the cumulative total of events responsible for ⩾80% of total management costs.
Since the base case analysis was conducted from the societal perspective, both direct and indirect costs were included in the model.
The base case analysis was conducted from the public health care payer perspective, considering the direct health care costs related to AK and its management in line with the Finnish [ 51] and most international guidelines (e.g., [ 52– 61]) on performing health economic assessments.
We conducted the base case analysis using site-specific wholesale prices of all treatment supplies, accounting for variation in the unit prices of 4LB kits, and variation in the types of SSB bandages assembled according to individual participants' leg circumferences and their varied unit prices.
Base case analysis, using the intention-to-treat results, and sensitivity analysis will be conducted by varying key model parameters and critical assumptions over plausible ranges/distributions.
One-way sensitivity analyses were conducted to examine how changes in key model parameters might affect the results of the base case analysis.
Sensitivity analyses (both simple and probabilistic) will be conducted as necessary to explore the importance of key uncertainties in any assumptions made in the base case analysis.
The base case analysis includes all costs.
a The base case analysis and complete case analysis are based on the societal perspective.
The base-case analysis was conducted to allow for comparability between this within-trial analysis and the reporting of the main RCT.
The base-case analysis is conducted from the perspective of the Australian mental health system and does not assume any particular distribution of children across the treatment alternatives.
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