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The base case analysis calculated the cost of the de Gramont regimen based on a mixture of in-patient and out-patient delivery.
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For example, the probability of successful ECV on the second trial used in our base case analysis was calculated to be 51%.
In our base case analysis, we calculated economic costs assuming that children born to women with mercury concentrations 3.5 4.84 μg/L suffer no loss in cognition, and that successive portions of the birth cohort experience loss of cognition associated with cord blood levels of 8.2, 9.9, 12.1, and 25.5 μg/L, respectively.
23 For the base case analysis, monthly costs were calculated according to the defined daily doses whereas an alternative scenario analysis was performed calculating monthly costs according to the mean dose (mean of minimum and maximum ranges taken from the summary of the product characteristics).
In the base case analysis, the AUC was calculated using a non-parametric trapezoidal method [ 23].
In the base case analysis, the drug daily cost was calculated on grounds of the social security reimbursement price, defined by the internal reference price system attached to the latest published positive drug list (May 2013) [ 37].
In the base case analysis, the average costs and effects were calculated for a hypothetical cohort of 1,000 patients.
The cost-utility is calculated as the cost per QALY gained in the base case analysis.
This cost estimate is used in the base case analysis.
The timeframe of the base case analysis was 5 years.
The base case analysis includes all costs.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com