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We estimated that at 60% lifetime efficacy, circumcision would reduce the lifetime risk of HIV diagnosis for all males by 15.7% in the base case analysis, and the reduction ranged from 7.9% among white males to 20.9% for black males (Table 3).
A base case analysis and sensitivity analyses were performed.
Analysis of the data is divided into a base case analysis and a sensitivity analysis.
a The base case analysis and complete case analysis are based on the societal perspective.
In the base case analysis and the analysis from the health care perspective missing data were multiply imputed.
The primary outcome was the discounted ICER, which was assessed in the base case analysis and various scenario and probabilistic sensitivity analyses.
Similar(39)
To assess the impact of data uncertainty on the economic outcomes of the base case analysis, univariate and probabilistic sensitivity analyses were performed, considering the model parameters and assumptions summarized in the Additional file 1: Table B.
In the base case analysis, CV and non-CV mortality was considered separately.
In the base case analysis, costs and clinical outcomes were projected over patient lifetimes, beyond the duration of intervention in the Steno-2 study.
Costs generated by ASE and OLA are slightly lower than the ones of the base case analysis (€31,219.7 and €31,528.4, respectively) due to savings in health state costs.
This sensitivity highlights the inadequacy of a base-case analysis and the need for probabilistic sensitivity analysis.
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