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For the base case analysis, a 2-dose AS04-adjuvanted HPV-16/18 HPV-16/18n combination with the current Pap smear screening programme, compared with the current Pap smear screening programme alone, was assessed.
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In the base case analysis, an average of £37 or 78% of the cost of aprepitant was offset due to the better efficacy of the aprepitant regimen compared with the regimen representing the UK standard of care.
Analysis of the data is divided into a base case analysis and a sensitivity analysis.
The statistical analysis of the collected data is divided into two separate data analyses: a base case analysis and a sensitivity analysis.
In our base case analysis, adding a proton pump inhibitor to a COX 2 selective inhibitor (used at the lowest licensed dose) was a cost effective option, even for patients at low risk of gastrointestinal adverse events (incremental cost effectiveness ratio approximately £10 000).
A probabilistic sensitivity analysis demonstrated the robustness of the base case analysis, with a 93% probability of being below $20,000 per QALY gained and a 99% probability of being below $30,000 per QALY gained.
In the base case analysis, strategy A ('usual care') cost $24,268 and yielded 2.015 QALYs for a patient over a 5-year period.
In this analysis the probability was changed from the 60% in the base case analysis to a range from 0%to100%0%to100%
Our base case analysis took a conservative approach to estimating equipment costs, allocating the entire costs of scales and stadiometers to the intervention.
16 The base case analysis used a lifetime time horizon to capture the short-term and long-term impacts of antiplatelet therapy on death and nonfatal cardiovascular events.
Therefore, a justification of the rationale of each scenario analysis is important for interpretation of the results of the base case analysis of a BIA and the associated uncertainty in BIA outcomes.
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