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In conclusion, mass enlargement and the presence or occurrence over time of subclinical endocrine alterations are frequent and not correlated, can appear at any time, are not associated with any basal predictor and, finally, are not necessarily indicative of malignant transformation or of progression toward overt disease.
In addition, we observed that mass increase and the development of new hormonal abnormalities over time are not correlated, can appear at any time, are not associated with any basal predictor and, finally, that are not necessarily indicative of malignant transformation or progression toward overt disease.
In addition, the risk of mass enlargement was constant over time and no basal predictor was present either with regard to morphological characteristics, such as initial mass dimensions, or functional status, such as the presence of subclinical endocrine alterations at entry.
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