Sentence examples for basal levels of activated from inspiring English sources

In vitro, basal levels of activated (phosphorylated) MAPK and extracellular-regulated kinase (ERK) 1/2 were higher in female compared to male astrocytes.

In addition, the Hpo pathway maintains tissue homeostasis by regulating the balance between diap1 expression and basal levels of activated caspases via the control of Dronc (Drosophila Nedd-2-like caspase orthologous to human Caspase 9) (Verghese et al., 2012).

Yang et al [ 8] reported that several cell lines, including a subset of those used in this study (BxPC-3, MCF-7, and SW-620) exhibited high basal levels of activated caspase-3 and -8 activity in the absence of other markers of apoptosis.

Basal levels of activated Akt are high in constitutively active Akt1 transgenic muscle [29], but not in Mstn−/− muscle (Fig. 4).

By performing MTT assay on C666-1, HONE1HONE1 and immortalized NP460 cells, we found that berberine has low toxicity towards the cells with low basal levels of activated STAT3, but has higher toxicity towards HONE1 cell line, which has constitutively activated STAT3.

These data suggested that U87MG cells have elevated basal levels of activated ERK most probably due to the constitutively active EGFR pathway and that PKCι depletion affects ERK induction.

It is not known if the regulation of the basal levels of activity of SFK differs from the regulatory processes controlling SFK activated by extracellular stimuli such as Albumin or growth factors.

Net1 knockdown cells displayed lower basal levels of active RhoA in the nucleus than control cells, and failed to activate the nuclear RhoA fraction in response to IR (Figure 4E F).

In this manuscript, we show that Wit rapidly inhibits not only basal levels of constitutively activated STAT3 but also inhibits growth factor- (e.g., EGF and PDGF) and cytokine- (e.g., IL-6, IFN- β and GM-CSF) stimulated STAT3 and STAT5 tyrosine phosphorylation.

However, whether Rac1 was actually activated by K-Ras or merely necessary at a basal level of activity for K-Ras induced effects was not determined [17].

After TCP stage, DREB2A keeps steadily activated; until HP stage, it begins to restore to their basal level of activity.