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Variation in basal levels of DOC resulted in heritability values of ∼0.37 and ∼0.32 even though basal levels did not significantly differ between the parental strains.
The net increase in cGMP above basal levels did not show saturation within the range of SNP doses tested.
This study demonstrated predominantly low-levels of XIAP expression in patient samples and varied expression levels in the GBM cell lines and these basal levels did not correlate with the PFS times of GBM patients, nor with the susceptibility of GBM cell lines to undergo apoptosis.
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Our data indicate that wt p53 at basal levels does not bind its target sites and that the presence of a mt p53 can block elevated levels of wt p53 from binding target promoters.
Basal GDNF levels did not differ among wild-type, mGlu2−/− and mGlu3−/− mice (Fig. 4A).
Significantly, in HeLa cells exposed exclusively to dHV.68/5'3'.F50 (i.e. hcAd.FLPe.F50-negative cells), the basal Rep68 levels did not suffice to disrupt AAVS1 loci and, in agreement with this observation, no targeted DNA insertion could be detected in any of the 40 clones that were analyzed (Fig. 6).
Basal cytokine levels did not differ between the three genotypes.
Despite sex differences in a display of stress-related behaviors, basal transcript levels did not predict the intensity of the behavioral display.
Given that high basal PON2 levels did not correlate with high sensitivity to its knock-down, future studies should test larger tumor cell panels for PON2 deficiency-simulated cell death.
We also observed higher basal levels of p-SFKs, whereas basal p-SYK levels did not reach statistical significance, possibly due to low number of patients.
Although basal urinary testosterone levels did not differ between males that sired the majority of pups in a litter and males that sired few or none of the pups in a litter, aggression and/or other physiological measures of fertility (e.g., penile reflexes) may differ between males that are attractive to females and those that have a reproductive advantage.
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