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Supernatant was harvested and analyzed after 5 min. The basal level was defined as 100%.
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The significance level was defined at ≤0.05.
Of the three measures, the mean basal level was calculated.
Hyperinsulinemia in the basal state was defined as fasting insulin levels at baseline in the upper quintile (Q5) of the study sample.
The basal subtype was defined as negative for both ER and ERBB2.
The basal-like type was defined as tumors expressing either EGFR or CK5/6, which are specific basal markers.
The basal level of the light intensity was defined as the level of wild-type (WT) lenses that do not scatter light.
The basal-like subtype was defined as triple negative.
The pseudo-plateau level of diversity was defined both by the fitness gain of additional driver mutations s d and by the basal mutation rate μ.
Basal EGFR expression (EGFRlow) was defined as 10-49% of tumour cells staining positively for EGFR.
Thyroid stimulating hormone deficiency was defined by thyroxin level less than 12 pmol/L and adrenocorticotrophin deficiency by basal blood cortisol at 08.00 h less than 70 µg/L.
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