These results suggest that active cellular uptake of HCO3- can contribute to the basal level of cellular cAMP in tissues that express sAC.
The non-neoplastic tissue was mildly brighter after 2-NBDG incubation, which probably reflects the basal level of glucose uptake in normal tissue.
TcNPR1 transcript was detected in all tissues tested, an expression pattern similar to the Arabidopsis gene, however, the basal level of expression varies among different tissues.
Nrf2 knockout mice have normal embryonic development and their basal level of antioxidant status in many tissues is not different from wild type mice [11].
IGFBP-1 is a potent inhibitor of IGF-1 in vivo [ 40], suggesting that the elevated basal level of IGFBP-1 in adipose tissues in SirT1ko/ko mice could reduce the effect of IGF-1.
These data demonstrate strongly that cis-regulatory DNA variants control the basal level of gene expression in a variety of tissues, including blood, and contribute to the neurologic phenotypes in the mouse.
They then analyzed the autophagy induction process either in tissues where the basal level of autophagy is almost undetectable (e. g. ovarian follicular cells) or in the fat body, an adipose tissue where autophagy is rapidly induced in starvation (aminoacids) conditions.
It was therefore tempting to speculate that Toll-9 may play a role in localized epithelial defense by maintaining a basal level of antimicrobial peptides in the gut, a tissue in constant contact with microorganisms.
Furthermore, tumor tissues from the established Bel-7402 model model had consistently high expression of TYMP and TK1 by IHC analysis, whereas the mouse normal liver tissue showed only basal level of either protein (panels F-H versus panels E, Figure 5b).
Moreover, in the adult, constitutive basal level of TRAF4 expression is observed in most tissues, suggesting a generic biological function for this protein.
