Sentence examples for basal level of activated from inspiring English sources
Since, activation of MMPs by plasminogen occurs through uPA-dependent plasmin generation (Ramos-DeSimone et al, 1999), it can be suggested that enhanced expression of uPAR is critical for sustaining basal level of activated Erk requisite for the secretion of pro-MMPs and plasminogen-mediated activation of the proteinases in colon cancer cells.
In their study, this discrepancy partially depends on the basal level of activated AKT because enforced expression of AKT reduced the effect of W7 expression.
Endogenously produced uPA was found to be a major determinant of the basal level of activated ERK1/2 and prevented apoptosis in metastatic MDA-MB-231 cells [ 57].
Moreover, recently it has been shown that endogenously produced uPA is a major determinant of the basal level of activated Erk in an aggressive breast cancer cell line (Ma et al, 2001).
Hence, the ability of uPA/uPAR system to sustain elevated basal level of activated Erk may represent a mechanism whereby uPA/uPAR system may affect cancer progression and distant metastasis in vivo.
In the presence of PD98059, an inhibitor of mitogen-activated protein kinase kinase 1 (MEK1K1, MEK1), the basal level of activated ERK1/2 was significantly reduced, and more pronounced decrease was observed in the presence of both PD98059 and TGF- β1.
In vitro, basal levels of activated (phosphorylated) MAPK and extracellular-regulated kinase (ERK) 1/2 were higher in female compared to male astrocytes.
In addition, the Hpo pathway maintains tissue homeostasis by regulating the balance between diap1 expression and basal levels of activated caspases via the control of Dronc (Drosophila Nedd-2-like caspase orthologous to human Caspase 9) (Verghese et al., 2012).
However, whether Rac1 was actually activated by K-Ras or merely necessary at a basal level of activity for K-Ras induced effects was not determined [17].
After TCP stage, DREB2A keeps steadily activated; until HP stage, it begins to restore to their basal level of activity.
