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Furthermore, for simplicity, the basal expression rates of these three genes are assumed to be zero.
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The inset of Figure 3C shows how the basal expression rate changes as a function of time.
In the case of silencing, the respective basal expression rate is damped by a factor of 10, while in the vector overexpression case, the basal rate is 10-fold higher.
The parameters α0, α1 and β denote the basal expression rate, the NFAT-induced expression rate constant, and the degradation rate constant, respectively.
The dynamics of the model are described by the two rate equations: (6) (7) where variables x and y represent the concentrations of the two gene products, and parameters B X and B Y denote the basal (constitutive) expression rates of genes x and y, respectively.
These data suggest that, although GF and SPF mice usually do not express IFN-α, or do so at extremely low levels, once the stimulatory signals are triggered, they might produce different levels of IFN-α due to the difference in basal expression levels of rate-limiting regulatory factors of IFN-α production.
HC11 cells constitutively expressing s80HER4 exhibited basal expression of differentiation markers, increased basal STAT5A activity and three-dimensional lumen formation.
A plot of CV of the basal expression level of rel as a function of time (Figure 3C) showed a similar variation as the transition rate, with the maxima in both the curves occurring around the same time.
Interestingly, without the palmitate treatment, Yap1 knockdown did not influence the basal expression level of CTGF (Fig. 4E and 4F).
DAC treatment barely changed basal expression levels of SOCS6.
Additionally, Hap1p controls Upc2p expression to maintain basal expression levels of ERG genes.
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