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To compare long-acting insulin glargine (Lantus) with intermediate-acting insulin (neutral protamine Hagedorn [NPH]/Lente) when used as the basal component of a multiple daily injection (MDI) regimen with prandial insulin lispro (Humalog) in adolescents with type 1 diabetes mellitus (T1DM).
In conclusion, the results of this study suggest that the use of insulin glargine as the basal component of a multiple injection regimen appears to be associated with a reduction in glycemic variability.
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We conducted a systematic review of health economic evaluations comparing GLA versus NPH as the basal component of an ICT in type 1 diabetes.
The aim of the present study was to systematically review the published health economic evaluations comparing GLA with NPH as the basal component of an ICT in patients with type 1 diabetes.
This is the first study to compare once-daily and twice-daily regimens of detemir as the basal component of basal-bolus therapy in a randomized trial design.
In addition, their transcripts were also accumulated at both biotrophic- and necrotrophic- in planta developmental stages, suggesting that CIH1 glycoprotein is a basal component of the cell wall of C. truncatum as described previously [ 20].
These at the point of conjuncture form the glenoid fossa, which articulates with the basal component of the skeleton of the limb.
It is therefore encouraging that this risk appears to be further reduced with IDegAsp, and this finding is also consistent with comparative studies of IDeg (the basal component of IDegAsp) versus insulin glargine when used in basal-bolus therapy (19) or as initial basal insulin therapy in type 2 diabetes (36).
A clear separation of the PD effects of the bolus and basal components of IDegAsp was hypothesized to carry a lower risk of hypoglycemia than can be achieved with conventional premixed insulin products, and a proof-of-concept study has indeed demonstrated lower rates of confirmed and nocturnal hypoglycemia comparing IDegAsp to biphasic IAsp in type 2 diabetes (23).
Among the well-characterized NF-κB coactivators, p300/CREB-binding protein (CBP) appear to be the basal components of functional NF-κB transcription complex [11], [12].
We recently showed that MLV-derived vectors integrate preferentially in hot spots around cell-specific genes, enriched in defined subsets of transcription factor binding sites (TFBSs), and suggested that MLV pre-integration complexes (PICs) are tethered to transcriptionally active regulatory regions engaged by basal components of the RNA polymerase II (Pol II) transcriptional machinery [15], [16].
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