Sentence examples for basal activity that is from inspiring English sources
Agonist-unbound GPCRs usually show basal activity that is enhanced by agonist binding, reduced by inverse agonist binding, unaffected by neutral antagonists and increased by mutations that lead to constitutively active mutants (CAMs).
We found that basal activity that is mainly contributed by PLD2 was unaffected.
MC4R also has intrinsic basal activity that is suppressed by the inverse agonist agouti-related peptide (AGRP) [22].
These cAMP concentration estimations confirmed that the double mutations on Ser and Ser did not affect catalytic activity of AC2, and the phosphomimetic S490/543D mutation possesses a higher basal activity that is refractory to further stimulation by PKC.
This model could also help explain the increase in the basal activity that is observed following MβCD treatment with the AC8 N-glycosylation-deficient mutants and wild-type AC8, for instance, reflecting a direct or indirect association between AC8 and a putative lipid raft associated protein, which exerts a tonic inhibitory influence on basal activity.
However, we observed that Chk1D469G had significantly reduced basal activity that was stimulated greater than two-fold in response to damage and was apparently sufficient to enforce a mitotic delay.
In our luciferase reporter studies with MCF 7 cells we observed that the promoter fragment that extended approximately 1.5 kb upstream from the translation start site showed basal activity that was relatively high in comparison to the other promoter-reporter constructs tested.
This suggests that full-length Bid has a basal proapoptotic activity that is increased by phosphorylation on S66.
The other study demonstrated that glioblastoma cells exhibit a basal constitutive caspase activity that is sufficient to promote migratory and invasive activities [30].
This study demonstrates that hMSC are endowed with a basal Hedgehog signaling activity that is necessary for efficient proliferation and clonogenicity of hMSC.
Further, they have substantial basal Lyn kinase activity that is un-responsive to IgM stimulation, unlike that seen in non-malignant cells.
