Sentence examples for basal activation of the from inspiring English sources

Specifically, minimal levels of Epo which lead to a basal activation of the MEK and Erk kinases moderately activate the class Ib PI3 kinase isoform PI3Kγ.

INCENP binding to Aurora B increases basal activation of the kinase, which then achieves full activity via a feedback loop following phosphorylation of the bound INCENP at a TSS motif proximal to the C-terminus [ 63,64].

In this context it is interesting to note that Ro5-4864 did not change the basal activation of the MCs indicating a selective action of BDZs at (pathologically) activated MCs.

This suggests that, if residual estrogens are present in the culture medium, they can produce some basal activation of the fusion protein, even in its optimal "EIE" configuration.

Cell signaling was also affected with the basal activation of the stress kinases sAPK/JNK1/2; and deficits in TCR-induced Ca2+ influx and phosphorylation and degradation of the inhibitor of NF-κB (IκB).

The ERK5 alone had no effect on FSHβ mRNA levels, indicating a lack of basal activation of the pathway under these conditions, but it further enhanced the effect of MEK5(D).

Trastuzumab, however, blocks basal activation of this pathway as evidenced by the downregulation of both HER3PI3K and pAkt/tAkt in BT474 (p-values <0.006).

A strong basal activation of this pathway as assessed by phosphorylation of m-TOR at 2448 and 2481 phosphorylation sites, a read out of p-mTOR activation was observed in HepG2 cells.

The multifactorial perturbations were induced by slightly increasing or decreasing the basal activation of all the genes in the network simultaneously by different random amounts [5].

How this "supra-basal" activation of the immune system is compatible with a better cardiac function?

Multifactorial perturbations were simulated by slightly increasing or decreasing the basal activation of all genes of the network simultaneously by different random amounts.