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Although the blood brain barrier presents a hurdle to the delivery of genes to the central nervous system from the periphery, several groups have been successful in transducing AAV serotype 9 (AAV9) to foetal, neonatal and adult animal motor neurons in the spinal cord via intravenous administration (Benkhelifa-Ziyyat et al, 2013; Dayton et al, 2012; Duque et al, 2009; Foust et al, 2009).
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A waterproof diffusion barrier presenting a good electric insulation is finally obtained and the protective performances were tested on specimens to assess their behavior under aggressive conditions.
As I wrote recently, siloed behavior continues to plague the enterprise and breaking down these barriers presents a huge challenge for organizations.
The capacity of influenza A to cross species barriers presents a potential threat to human health.
Overcoming these barriers presents a challenge to achieving improved hygiene in these communities.
The steric modulations further assist the pendent groups to overcome the torsional barriers presenting a larger accessible potential energy surface [ 47].
Given the characteristics of alcohol dependence including disorganization (Bauer, 1982), decreased ability to make judgements, cognitive impairment (Oscar-Berman et al., 1997) and fluctuating motivation these barriers present a significant challenge for the continuing attendance of individuals.
(Grode) 'Still More of Our Parts' (opens on Thursday) The last time Theater Breaking Through Barriers presented an evening of short plays about life with disabilities, Anita Gates, in her review for The New York Times, called it "a largely entertaining and worthwhile mini-evening".
In multicultural, multilingual contexts, language barriers present an important challenge to effective patient-provider communication [ 2- 4].
The blood brain barrier (BBB) presents a challenge for the delivery of brain therapeutics.
The blood CNS barrier also presents a major obstacle for potential CNS medicines.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com