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Daneman, R., Zhou, L., Kebede, A. A. & Barres, B. A. Pericytes are required for blood brain barrier integrity during embryogenesis.
Daneman, R., Zhou, L., Kebede, A. A. & Barres, B. A. Pericytes are required for blood-brain barrier integrity during embryogenesis.
Daneman, R., Zhou, L., Kebede, A.A. & Barres, B.A. Pericytes are required for blood-brain barrier integrity during embryogenesis.
We found that GPR124 is essential for developmental brain angiogenesis (Kuhnert et al, Science 2010) and that GPR124 is critical for maintaining blood-brain barrier integrity during stroke and brain tumor growth (Chang et al, Nat Med 2017).
Compounds, which have been used successfully for treatment of lung epithelial injury were tested for their ability to protect barrier integrity during LT exposure [26] [28].
However, the molecular events underlying IEC shedding and disruption of intestinal barrier integrity during inflammatory disease states remain poorly understood.
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Thus, independent, non-invasive techniques are needed to quantify the barrier integrity continuously during the experiment.
After addition of PBCA-NP to porcine endothelial cells, a drastic decrease in barrier integrity was observed during 2 h, followed by a recovery of the barrier within the next 3 - 4 h.
Furthermore, loss of blood-labyrinth barrier integrity occurs early and prominently during noise-induced hearing loss [7].
In summary, our study demonstrates for the first time that MARCKS is required for maintaining the ependymal barrier integrity and sustaining forebrain homeostasis during normal aging.
After each experiment, TEER values were in the same range as before the assay (or even higher), suggesting that cell monolayers were robust during the experiment and barrier integrity was maintained.
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