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The allostatic load exhibited by the mimicked husbandry conditions in the present study resulted in decreased intestinal barrier functions as evident by increased intestinal permeability.
The microtubes also exhibited cellular barrier functions as low porosity tubes prevented outward migration of GFP-transduced HUVECs, while the high porosity microtubes allowed a few cells per tube to migrate outward during perfusion.
This conclusion is further supported by the observation that although increased cell shedding was observed in response to 5-HT beginning 4 hours, the barrier functions as measured by transepithelial electrical resistance (TEER), is not substantially compromised until 48 hours (Figure 4).
The intestinal barrier functions as one of the first lines of defense against microbial pathogens [ 55].
This barrier functions as a sieve allowing transendothelial transport of molecules but inhibiting cellular extravasation.
First, the AEC barrier functions as a mechanical barrier between the lumen and the underlying submucosa, to defend the tissue from bacteria, virus, allergens, and other noxious substances [ 14].
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Nevertheless, there has been a significant improvement regarding the functional and histological quality of healed skin, assessed through its epidermal barrier function as well as dermal mechanical property.
Cold winds can damage the skin's surface, impairing its barrier function, as well as boosting the rate at which moisture evaporates from it.
AhR play important roles in the intestinal mucosal immune response and the regulation of the intestinal barrier function, as well as in antioxidant and xenobiotic responses72,73.
Brain pericytes (BrPCs) are essential cellular components of the central nervous system neurovascular unit involved in the regulation of blood flow, blood brain barrier function, as well as in the stabilization of the vessel architecture.
Next to this physical barrier, chemical substances take part in the barrier function as well.
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