Exact(2)
For at least 2 months of age, the functional activity of the strial marginal cells, as well as the barrier function of the stria vascularis, remains intact during EP establishment in ILDR1-deficient mice.
Although occludin was also expressed in marginal cells and basal cells of the stria vascularis, the barrier function of the stria vascularis was not affected either (data not shown).
Similar(56)
Furthermore, adult Ildr1 w−/− mice had a positive EP of normal magnitude (100 ± 12 mV, n = 7) compared with Ildr1 w+/+ littermates (91 ± 14 mV, n = 7, Fig. 4C), indicating that the barrier function of the cochlear epithelia was not impaired and that stria vascularis was still functional.
Ulceration could disrupt the mucosal barrier and thereby abrogated the protective barrier function of the epithelium.
A modified barrier dye penetration assay [41] was carried out to determine the barrier function of skin.
Ultimately, the barrier function of epithelium is lost thereby.
Many factors contribute to the barrier function of skin.
This is the first gene therapy study in successfully preventing the development of deafness in the adult stage of a mouse model of JLN syndrome caused by gene defects specifically affecting the function of the stria vascularis (SV).
If you look at the pathology of human deafness, the function of the stria vascularis and the outer hair cells are two of the key things that can go wrong.
Our results demonstrate the first successful gene therapy treatment for gene defects specifically affecting the function of the stria vascularis, which is a major site affected by genetic mutations in inherited hearing loss.
In addition, claudin-11 knockout mice developed deafness due to selective disruption of the barrier function with disappearance of TJs between basal cells of the stria vascularis (Gow et al., 2004; Kitajiri et al., 2004b).
Write better and faster with AI suggestions while staying true to your unique style.
Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com