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This decreases the barrier function of the epidermis allowing moisture to be released from the skin, causing dryness.
It is possible that the increased proliferation may reflect a secondary response to the compromised barrier function of the epidermis.
Normal fatty acid metabolism is critical to the permeability barrier function of the epidermis.
Measurement of TEWL was used for studying the water barrier function of the epidermis.
The effect of histamine on the barrier function of the epidermis was tested by investigating the transdermal diffusion of tracer molecules.
6 7 The filaggrin gene resides on human chromosome 1q21 within the epidermal differentiation complex, a region that also harbours genes for several other proteins that are important for the normal barrier function of the epidermis.
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The skin of FABP5 knockout mice appears normal at the gross and histological level, but the water-barrier function of the epidermis is altered in these mice.
The barrier function of the human epidermis is supposed to be governed by lipid composition and organization in the stratum corneum.
In the oxazolone induced atopic dermatitis model, the topical activation of PPARα by WY-14643 could normalize the structure of epidermis, significantly improved barrier function of the skin and increased stratum corneum hydration as well as reversed the immunologic abnormalities.
The uppermost layer of the epidermis, the stratum corneum (SC), comprises the main barrier function of the skin.
The barrier function of skin relies on the density and the hydrophobic nature of the top layer of the epidermis, the cornified envelope (CE).
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