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Impaired gut epithelial barrier function may lead to persistent immune reactions, thus augmenting the gut inflammation [ 6].
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Consequently, dysregulation of miRNA function may lead to atherosclerosis.
51 Hence, poor cognitive function may lead to depression.
For example, inflammation may lead to declining kidney function, or reduced kidney function may lead to elevated inflammatory biomarkers.
Furthermore, early regeneration of mucosal gut barrier function may decrease infectious complications and improve patient outcome.
In addition, conditions with reduced skin barrier function may enlarge the taken up fraction of particles.
The disorders of this barrier function may be defined by altered permeability to different substances.
Intestinal epithelial barrier function may be compromised in response to PAR2 activation [ 55].
This finding is important because senescence represents a major intrinsic barrier to malignant transformation [ 101] although this barrier function may only be transient.
The intestinal barrier function may suffer from 5-FU cytotoxic insults in various ways, including mucosal inflammatory reactions, intestinal epithelial barrier disruption, and bacterial translocation [ 20].
In addition to transcriptional and translational regulation of expression levels, barrier function may be influenced by Cldn subcellular localization.
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