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Intestinal epithelial barrier function is regulated by epithelial cells, innate and adaptive immunity, and the enteric nervous system and dysregulation of any of these alters the barrier [27].
Recent experimental data in animals indicate now that the intestinal barrier function is regulated in vivo through activation of the intestinal cannabinoid type 1 receptor (CB1R).
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Reproductive function is regulated by hormonal signalling.
MMP function is regulated at several levels.
How might ztf-16 function be regulated?
Gastroesophageal reflux disease (GERD) is associated with impaired epithelial barrier function that is regulated by cell-cell contacts.
The precise role of occludin in regulating barrier function is currently unclear, although, occludin is implicated in regulation of gastric barrier function [ 82], and emerging evidence suggests an important role for occludin in mediating barrier permeability.
However, whether NHE1 activation directly regulates microvascular barrier function is not known.
Thus, a better understanding of the molecular mechanisms regulating endothelial barrier function is required for developing new therapies for these diseases.
The normal barrier function is maintained by steady enterocyte turnover finely regulated by cell proliferation, migration, and apoptosis.
Barrier function is mediated by tight and adherens barrier proteins between adjacent ECs.
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