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Mereu, A., Tedó, G., Moeser, A. J., Rimbach, G. & Ipharraguerre, I. R. Cromolyn-mediated improvement of intestinal barrier function is associated with enhanced piglet performance after weaning.
Disruption of gastrointestinal homeostasis, as a result of impaired barrier function, is associated with numerous pathologies including inflammatory bowel disease and colorectal cancer.
Impairment of the intestinal barrier function is associated with loss of tight junction proteins, including occludin and ZO-1.
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Events leading to compromised barrier function are associated with various intestinal disorders including inflammatory bowel diseases (IBD) (Williams et al., 2001; Sartor, 2008).
Defects in epithelial barrier function are associated with human disorders in multiple organs including atopic dermatitis, allergen response in respiratory tracts, and gastrointestinal inflammation (Segre, 2006).
Failing thymus function is associated with immunodeficiency and/or autoimmunity.
Abnormal vascular permeability caused by disorder in barrier function is often associated with various pathological states such as tumor progression or pulmonary fibrosis.
Dysregulation of keratinocyte differentiation together with pathologic changes in this natural barrier function is commonly associated with skin diseases such as atopic dermatitis, psoriasis, and ichthyosis vulgaris (2– 4).
One SNP, located in a gene related to skin barrier function, was significantly associated with C. jeikeium.
This leads to an impaired barrier function which is associated with increased paracellular permeability.
Indeed, disrupted intestinal barrier function, which is associated with alcohol consumption, in combination with alcohol-induced bacterial overgrowth and dysbiosis, could be highly relevant for the development of alcohol-induced liver pathology, including nonalcoholic fatty liver disease (NAFLD), nonalcoholic steatohepatitis (NASH), and ALD.
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