Sentence examples for barrier function have been from inspiring English sources

Despite recent insights into the molecular mechanisms of fibroblast aging, age-related changes of the skin barrier function have been understudied.

Defects in intestinal barrier function have been associated with intestinal inflammatory disease.

The effects of the permeation enhancer, oleic acid (OA), on skin barrier function have been widely studied.

Importantly, the postulated roles for Map and EspF in disrupting barrier function have been validated in vivo (Shifflett et al., 2005; Ma et al., 2006).

In humans, regional variations of skin lipid composition and barrier function have been described [ 16- 19], but a correlation between lipid composition and barrier properties was not determined [ 18].

Altered intestinal epithelial barrier function has been suggested to play a role in the causation of HAEC.

The importance of Cldns in epidermal differentiation and barrier function has been confirmed by experiments in which Cldn expression has been perturbed in epidermal cells; for example, Cldn1 knockout mice die shortly after birth due to skin barrier dysfunction [14].

The intimate connection of Gln-enriched proteins to an epidermal barrier function has been proven in human skin diseases [40] and in transgenic mice overexpressing claudin-6, i.e., tight junction protein in the epidermis [41].

The critical role of filaggrin in epidermis homeostasis and barrier function has been evidenced by the recent disclosure that loss-of-function mutations in the filaggrin gene underlie ichthyosis vulgaris (OMIM #146700) and are strong predisposing factors for atopic dermatitis (OMIM %603165)[10].

Impaired barrier function has been implicated in the pathogenesis of inflammatory bowel disease (IBD).

Endotoxemia, a marker of impaired intestinal barrier function, has been identified across the full spectrum of CKD, with levels of circulating endotoxins increasing with declining kidney function [ 64].