Sentence examples for barrier function has been from inspiring English sources
Altered intestinal epithelial barrier function has been suggested to play a role in the causation of HAEC.
The intimate connection of Gln-enriched proteins to an epidermal barrier function has been proven in human skin diseases [40] and in transgenic mice overexpressing claudin-6, i.e., tight junction protein in the epidermis [41].
The importance of Cldns in epidermal differentiation and barrier function has been confirmed by experiments in which Cldn expression has been perturbed in epidermal cells; for example, Cldn1 knockout mice die shortly after birth due to skin barrier dysfunction [14].
The critical role of filaggrin in epidermis homeostasis and barrier function has been evidenced by the recent disclosure that loss-of-function mutations in the filaggrin gene underlie ichthyosis vulgaris (OMIM #146700) and are strong predisposing factors for atopic dermatitis (OMIM %603165)[10].
Impaired barrier function has been implicated in the pathogenesis of inflammatory bowel disease (IBD).
The importance of JAM-A in endothelial and epithelial barrier function has been studied previously (Liu et al, 2000; Mandell et al, 2005, 2006, 2007).
Despite recent insights into the molecular mechanisms of fibroblast aging, age-related changes of the skin barrier function have been understudied.
Importantly, the postulated roles for Map and EspF in disrupting barrier function have been validated in vivo (Shifflett et al., 2005; Ma et al., 2006).
In humans, regional variations of skin lipid composition and barrier function have been described [ 16- 19], but a correlation between lipid composition and barrier properties was not determined [ 18].
