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Of note, we also established a novel porcine choroid plexus epithelial cell line (PCP-R), which displays important features of a functional BCSFB in vitro model, i.e. the formation of a strong barrier function as demonstrated by a high TEER and a low permeability for macromolecules [ 33].
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Cold winds can damage the skin's surface, impairing its barrier function, as well as boosting the rate at which moisture evaporates from it.
Next to this physical barrier, chemical substances take part in the barrier function as well.
Fixed low DO levels reduce the intestinal barrier function as well as absorbing functions.
Glutamine administration may improve gut barrier function as well as lymphocyte function, and this could potentially reduce infectious complications.
For the in vivo data set, analysis of the epithelial barrier defense sub-model predicted that exposure to CS activates mechanisms that lead to decreased epithelial cell barrier function, as well as compensatory mechanisms to restore barrier function.
Mice exposed to DSS demonstrated significant increase in serum FITC compared to water controls as previously noted 32; netrin-1 treatment had no effect on barrier function as measured by serum FITC levels (figure 6B).
Disruption of this barrier function as seen during inflammatory processes leads to microvascular hyperpermeability [ 9].
The FOS induced increase in intestinal permeability reduces intestinal barrier function as reported earlier [ 5].
This barrier functions as a sieve allowing transendothelial transport of molecules but inhibiting cellular extravasation.
The intestinal barrier functions as one of the first lines of defense against microbial pathogens [ 55].
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